Contraindicated (one)pentobarbital will lessen the extent or influence of roflumilast by influencing hepatic/intestinal enzyme CYP3A4 metabolism.Barbiturates can induce hepatic microsomal enzymes resulting in increased metabolism and reduced anticoagulant reaction of oral anticoagulants (eg, warfarin, acenocoumarol, dicumarol, and phenprocoumon); s